AustralieFrV1, Main, Exploration, bibRecord, 001E36

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

Identifieur interne : 001E36 ( Main/Exploration ); précédent : 001E35; suivant : 001E37

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

Auteurs : Craig C. Teerlink [États-Unis] ; Daniel Leongamornlert [Royaume-Uni] ; Tokhir Dadaev [Royaume-Uni] ; Alun Thomas [États-Unis] ; James Farnham [États-Unis] ; Robert A. Stephenson [États-Unis] ; Shaun Riska [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Daniel J. Schaid [États-Unis] ; William J. Catalona [États-Unis] ; S. Lilly Zheng [États-Unis] ; Kathleen A. Cooney [États-Unis] ; Anna M. Ray [États-Unis] ; Kimberly A. Zuhlke [États-Unis] ; Ethan M. Lange [États-Unis] ; Graham G. Giles [Australie] ; Melissa C. Southey [Australie] ; Liesel M. Fitzgerald [Australie] ; Antje Rinckleb [Allemagne] ; Manuel Luedeke [Allemagne] ; Christiane Maier [Allemagne] ; Janet L. Stanford [États-Unis] ; Elaine A. Ostrander [États-Unis] ; Elina M. Kaikkonen [Finlande] ; Csilla Sipeky [Finlande] ; Teuvo Tammela [Finlande] ; Johanna Schleutker [Finlande] ; Kathleen E. Wiley [États-Unis] ; Sarah D. Isaacs [États-Unis] ; Patrick C. Walsh [États-Unis] ; William B. Isaacs [États-Unis] ; Jianfeng Xu [États-Unis] ; Geraldine Cancel-Tassin [France] ; Olivier Cussenot [France] ; Diptasri Mandal [États-Unis] ; Cecelia Laurie [États-Unis] ; Cathy Laurie [États-Unis] ; Stephen N. Thibodeau [États-Unis] ; Rosalind A. Eeles [Royaume-Uni] ; Zsofia Kote-Jarai [Royaume-Uni] ; Lisa Cannon-Albright [États-Unis]

Source :

Human genetics [ 0340-6717 ] ; 2016.

RBID : PMC:5020907

Descripteurs français

KwdFr :
- ARN long non codant (génétique), Adulte d'âge moyen, Facteurs de risque, Fréquence d'allèle, Génotype, Haplotypes (génétique), Humains, Hétérozygote, Mâle, Pedigree, Polymorphisme de nucléotide simple, Protéines suppresseurs de tumeurs (génétique), Prédisposition génétique à une maladie, Sujet âgé, Tumeurs de la prostate (anatomopathologie), Tumeurs de la prostate (génétique), Étude d'association pangénomique.
MESH :
- anatomopathologie : Tumeurs de la prostate.
- génétique : ARN long non codant, Haplotypes, Protéines suppresseurs de tumeurs, Tumeurs de la prostate.
- Adulte d'âge moyen, Facteurs de risque, Fréquence d'allèle, Génotype, Humains, Hétérozygote, Mâle, Pedigree, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Sujet âgé, Étude d'association pangénomique.

English descriptors

KwdEn :
- Aged, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Haplotypes (genetics), Heterozygote, Humans, Male, Middle Aged, Pedigree, Polymorphism, Single Nucleotide, Prostatic Neoplasms (genetics), Prostatic Neoplasms (pathology), RNA, Long Noncoding (genetics), Risk Factors, Tumor Suppressor Proteins (genetics).
MESH :
- chemical , genetics : RNA, Long Noncoding, Tumor Suppressor Proteins.
- genetics : Haplotypes, Prostatic Neoplasms.
- pathology : Prostatic Neoplasms.
- Aged, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Heterozygote, Humans, Male, Middle Aged, Pedigree, Polymorphism, Single Nucleotide, Risk Factors.

Abstract

Previous genome-wide association studies (GWAS) of prostate cancer risk focused on cases unselected for family history and have reported over 100 significant associations. The International Consortium for Prostate Cancer Genetics (ICPCG) has now performed a GWAS of 2511 (unrelated) familial prostate cancer cases and 1382 unaffected controls from 12 member sites. All samples were genotyped on the Illumina 5M+exome single nucleotide polymorphism (SNP) platform. The GWAS identified a significant evidence for association for SNPs in six regions previously associated with prostate cancer in population-based cohorts, including 3q26.2, 6q25.3, 8q24.21, 10q11.23, 11q13.3, and 17q12. Of note, SNP rs138042437 (p = 1.7e⁻⁸) at 8q24.21 achieved a large estimated effect size in this cohort (odds ratio = 13.3). 116 previously sampled affected relatives of 62 risk-allele carriers from the GWAS cohort were genotyped for this SNP, identifying 78 additional affected carriers in 62 pedigrees. A test for an excess number of affected carriers among relatives exhibited strong evidence for co-segregation of the variant with disease (p = 8.5e⁻¹¹). The majority (92 %) of risk-allele carriers at rs138042437 had a consistent estimated haplotype spanning approximately 100 kb of 8q24.21 that contained the minor alleles of three rare SNPs (dosage minor allele frequencies <1.7 %), rs183373024 (PRNCR1), previously associated SNP rs188140481, and rs138042437 (CASC19). Strong evidence for co-segregation of a SNP on the haplotype further characterizes the haplotype as a prostate cancer pre-disposition locus.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020907

DOI: 10.1007/s00439-016-1690-6
PubMed: 27262462
PubMed Central: 5020907

Affiliations:

Le document en format XML

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<author><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name>
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<author><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program for Personalized Cancer Care, NorthShore University Health System, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
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<author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name>
<affiliation wicri:level="3"><nlm:aff id="A25">CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
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<author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name>
<affiliation wicri:level="3"><nlm:aff id="A25">CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
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<author><name sortKey="Mandal, Diptasri" sort="Mandal, Diptasri" uniqKey="Mandal D" first="Diptasri" last="Mandal">Diptasri Mandal</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112</wicri:regionArea>
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</placeName>
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<author><name sortKey="Laurie, Cecelia" sort="Laurie, Cecelia" uniqKey="Laurie C" first="Cecelia" last="Laurie">Cecelia Laurie</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA 98195</wicri:regionArea>
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<settlement type="city">Seattle</settlement>
</placeName>
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<author><name sortKey="Laurie, Cathy" sort="Laurie, Cathy" uniqKey="Laurie C" first="Cathy" last="Laurie">Cathy Laurie</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Biostatistics, University of Washington, Seattle, WA 98195, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
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</author>
<author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN 55905</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="A2">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP</wicri:regionArea>
<wicri:noRegion>London SW7 3RP</wicri:noRegion>
</affiliation>
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<author><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A29">George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148</wicri:regionArea>
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</placeName>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21</title>
<author><name sortKey="Teerlink, Craig C" sort="Teerlink, Craig C" uniqKey="Teerlink C" first="Craig C." last="Teerlink">Craig C. Teerlink</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leongamornlert, Daniel" sort="Leongamornlert, Daniel" uniqKey="Leongamornlert D" first="Daniel" last="Leongamornlert">Daniel Leongamornlert</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP</wicri:regionArea>
<wicri:noRegion>London SW7 3RP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dadaev, Tokhir" sort="Dadaev, Tokhir" uniqKey="Dadaev T" first="Tokhir" last="Dadaev">Tokhir Dadaev</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP</wicri:regionArea>
<wicri:noRegion>London SW7 3RP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomas, Alun" sort="Thomas, Alun" uniqKey="Thomas A" first="Alun" last="Thomas">Alun Thomas</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Farnham, James" sort="Farnham, James" uniqKey="Farnham J" first="James" last="Farnham">James Farnham</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stephenson, Robert A" sort="Stephenson, Robert A" uniqKey="Stephenson R" first="Robert A." last="Stephenson">Robert A. Stephenson</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Urology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of Utah School of Medicine, Salt Lake City, UT 84132</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84132</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riska, Shaun" sort="Riska, Shaun" uniqKey="Riska S" first="Shaun" last="Riska">Shaun Riska</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zuhlke, Kimberly A" sort="Zuhlke, Kimberly A" uniqKey="Zuhlke K" first="Kimberly A." last="Zuhlke">Kimberly A. Zuhlke</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A11">Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne 3004</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A13">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC 3004</wicri:regionArea>
<wicri:noRegion>VIC 3004</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="A15">Department of Pathology, University of Melbourne, Melbourne 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, University of Melbourne, Melbourne 3010</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne 3004, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne 3004</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Department of Urology, University Hospital Ulm, 53179 Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Urology, University Hospital Ulm, 53179 Ulm</wicri:regionArea>
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<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luedeke, Manuel" sort="Luedeke, Manuel" uniqKey="Luedeke M" first="Manuel" last="Luedeke">Manuel Luedeke</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Department of Urology, University Hospital Ulm, 53179 Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Urology, University Hospital Ulm, 53179 Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
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</affiliation>
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<author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
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<author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Genetics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaikkonen, Elina M" sort="Kaikkonen, Elina M" uniqKey="Kaikkonen E" first="Elina M." last="Kaikkonen">Elina M. Kaikkonen</name>
<affiliation wicri:level="4"><nlm:aff id="A20">Department of Medical Biochemistry and Genetics, University of Turku, 20520 Turku, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, 20520 Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
<settlement type="city">Turku</settlement>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
</author>
<author><name sortKey="Sipeky, Csilla" sort="Sipeky, Csilla" uniqKey="Sipeky C" first="Csilla" last="Sipeky">Csilla Sipeky</name>
<affiliation wicri:level="4"><nlm:aff id="A20">Department of Medical Biochemistry and Genetics, University of Turku, 20520 Turku, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, 20520 Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
<settlement type="city">Turku</settlement>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
</author>
<author><name sortKey="Tammela, Teuvo" sort="Tammela, Teuvo" uniqKey="Tammela T" first="Teuvo" last="Tammela">Teuvo Tammela</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Department of Urology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Urology, University of Tampere and Tampere University Hospital, 33520 Tampere</wicri:regionArea>
<wicri:noRegion>33520 Tampere</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, 20520 Turku, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, 20520 Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
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<author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Program for Personalized Cancer Care, NorthShore University Health System, Evanston, IL 60201, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program for Personalized Cancer Care, NorthShore University Health System, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name>
<affiliation wicri:level="3"><nlm:aff id="A25">CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name>
<affiliation wicri:level="3"><nlm:aff id="A25">CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CeRePP, Hopital Tenon, Assistance Publique-Hopitaux de Paris, 75020 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mandal, Diptasri" sort="Mandal, Diptasri" uniqKey="Mandal D" first="Diptasri" last="Mandal">Diptasri Mandal</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112</wicri:regionArea>
<placeName><region type="state">Louisiane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laurie, Cecelia" sort="Laurie, Cecelia" uniqKey="Laurie C" first="Cecelia" last="Laurie">Cecelia Laurie</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Biostatistics, University of Washington, Seattle, WA 98195, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Laurie, Cathy" sort="Laurie, Cathy" uniqKey="Laurie C" first="Cathy" last="Laurie">Cathy Laurie</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Department of Biostatistics, University of Washington, Seattle, WA 98195, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN 55905</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP</wicri:regionArea>
<wicri:noRegion>London SW7 3RP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, Institute of Cancer Research, London SW7 3RP</wicri:regionArea>
<wicri:noRegion>London SW7 3RP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84108</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A29">George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
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</analytic>
<series><title level="j">Human genetics</title>
<idno type="ISSN">0340-6717</idno>
<idno type="eISSN">1432-1203</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Haplotypes (genetics)</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pedigree</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Prostatic Neoplasms (genetics)</term>
<term>Prostatic Neoplasms (pathology)</term>
<term>RNA, Long Noncoding (genetics)</term>
<term>Risk Factors</term>
<term>Tumor Suppressor Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN long non codant (génétique)</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Haplotypes (génétique)</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Mâle</term>
<term>Pedigree</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sujet âgé</term>
<term>Tumeurs de la prostate (anatomopathologie)</term>
<term>Tumeurs de la prostate (génétique)</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Long Noncoding</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Haplotypes</term>
<term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN long non codant</term>
<term>Haplotypes</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Tumeurs de la prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pedigree</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Mâle</term>
<term>Pedigree</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition génétique à une maladie</term>
<term>Sujet âgé</term>
<term>Étude d'association pangénomique</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Previous genome-wide association studies (GWAS) of prostate cancer risk focused on cases unselected for family history and have reported over 100 significant associations. The International Consortium for Prostate Cancer Genetics (ICPCG) has now performed a GWAS of 2511 (unrelated) familial prostate cancer cases and 1382 unaffected controls from 12 member sites. All samples were genotyped on the Illumina 5M+exome single nucleotide polymorphism (SNP) platform. The GWAS identified a significant evidence for association for SNPs in six regions previously associated with prostate cancer in population-based cohorts, including 3q26.2, 6q25.3, 8q24.21, 10q11.23, 11q13.3, and 17q12. Of note, SNP rs138042437 (<italic>p</italic>
 = 1.7e<sup>−8</sup>
) at 8q24.21 achieved a large estimated effect size in this cohort (odds ratio = 13.3). 116 previously sampled affected relatives of 62 risk-allele carriers from the GWAS cohort were genotyped for this SNP, identifying 78 additional affected carriers in 62 pedigrees. A test for an excess number of affected carriers among relatives exhibited strong evidence for co-segregation of the variant with disease (<italic>p</italic>
 = 8.5e<sup>−11</sup>
). The majority (92 %) of risk-allele carriers at rs138042437 had a consistent estimated haplotype spanning approximately 100 kb of 8q24.21 that contained the minor alleles of three rare SNPs (dosage minor allele frequencies <1.7 %), rs183373024 (PRNCR1), previously associated SNP rs188140481, and rs138042437 (CASC19). Strong evidence for co-segregation of a SNP on the haplotype further characterizes the haplotype as a prostate cancer pre-disposition locus.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
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<li>Université de Turku</li>
<li>Université de Washington</li>
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<tree><country name="États-Unis"><region name="Utah"><name sortKey="Teerlink, Craig C" sort="Teerlink, Craig C" uniqKey="Teerlink C" first="Craig C." last="Teerlink">Craig C. Teerlink</name>
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<name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name>
<name sortKey="Cannon Albright, Lisa" sort="Cannon Albright, Lisa" uniqKey="Cannon Albright L" first="Lisa" last="Cannon-Albright">Lisa Cannon-Albright</name>
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<name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name>
<name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name>
<name sortKey="Farnham, James" sort="Farnham, James" uniqKey="Farnham J" first="James" last="Farnham">James Farnham</name>
<name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name>
<name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name>
<name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name>
<name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name>
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<name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name>
<name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name>
<name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name>
<name sortKey="Riska, Shaun" sort="Riska, Shaun" uniqKey="Riska S" first="Shaun" last="Riska">Shaun Riska</name>
<name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name>
<name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name>
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   |texte=   Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21
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Serveur d'exploration sur les relations entre la France et l'Australie

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

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	Serveur d'exploration sur les relations entre la France et l'Australie
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